Different Types of Membrane Proteins

  • Proteins are the basic building blocks of our biology, but we don't know much about many proteins, like membrane proteins that we're going to talk about today.

    Different membrane proteins

    There are many different membrane proteins, including transmembrane proteins that span across the membrane, Monotypic/peripheral membrane proteins that attached to the lipid bilayer or other integral proteins and peptide. The reason that membrane proteins studies are extremely important is that they are targets of over 50% of all modern drugs. It is estimated that 20-30% of all genes in most genomes encode membrane proteins. However, such proteins are inherently difficult to purify and characterize. The production of membrane protein is an urgent issue to handle with and optimize

    Peripheral proteins

    Peripheral proteins are one of membrane proteins, which consist of 20~30% of total encoding genes in the genome, play a critical role in multiple biological processes, including ligand-receptor binding, signal transduction, molecule transportation, intercellular recognition, and cell adhesion. Currently, there rises growing interest regarding membrane proteins as promising targets for various drug development and other applications.

    To obtain highly functional anti-membrane protein antibodies, expression and presentation of the membrane protein of interest as immunogen is the prerequisite. As most membrane proteins are partially or completely embedded in the lipid bilayer, traditional expression methods meet obstacles in presenting the native conformations, such as low expression level, difficult extraction, misfolding, and incomplete post-translational modifications.

    native membrane proteins

    Mempro™ cell-free protein production system is the innovative system to produce intergral membrane proteins which can bypass the limitations that encountered in cell-based protein production systems, such as host cell toxicity, low yield and solubilization and purification dependent on detergents. Membrane proteins differ from the water-soluble proteins via highly hydrophobic segments required for membrane insertion. However, this inherent hydrophobicity has hindered the study of structural information of membrane proteins. A simple point of integral membrane protein folding is that individual transmembrane segments serve as autonomous folding domains。

    Native proteins

    Versatile proteins from natural sources are used as medicinal agents as they are obtained using molecular tools. Unlike recombinant proteins, naturally isolated proteins do not have involved tags, and their molecular behavior, enzymatic activity, and other properties are under physiological conditions. Isolation and purification of a

    We provide a comprehensive list of membrane proteins, including:

    • Transmembrane Protein Production
    • 5-Lipoxygenase-Activating Protein
    • ABC Transporters
    • ACBP
    • Amyloid beta (A4)
    • Bcl-2 Inhibitors
    • BNIPs
    • CAAX protease
    • Cytochromes P450
    • E-NPPs
    • EPHA1
    • EPHA2
    • EPHA3
    • EPHA4
    • Fatty Acid Desaturases
    • Gamma secretase
    • Glucose transporter
    • Glycophorins
    • GPCR
    • HER2/ErbB2
    • HER3/ErbB3
    • HER4/ErbB4
    • HSD-11β Hypoxia-induced Proteins
    • Immunoglobulins
    • Insulin receptor
    • Integrins
    • Ion channel
    • MAPEG
    • MFS
    • MinK Family
    • MPPs
    • Peptidase AD
    • Peptidase Family M48
    • Peptidase MA
    • Protein Jagged
    • Receptor-type Kinases
    • SNARE Complex
    • Sulfatases
    • TNF receptor
    • Transmembrane Proteins 14
    • Transporter
    • TROBP
    • VEGF receptors
    • Aldehyde Dehydrogenases
    • Ammonia and Urea transporters
    • FMN-linked Oxidoreductases
    • Leucine Rich Repeat (LRR)-Containing Transmembrane Proteins
    • Leukotriene C4 synthase
    • Lysosome-associated membrane glycoprotein
    • Major Intrinsic Protein (MIP)/FNT superfamily
    • Microsomal prostaglandin E synthase
    • N-(deoxy)ribosyltransferase-like Membrane Proteins
    • Neutral/alkaline Ceramidases
    • Oligosaccharyl Transferase
    • Pentameric Ligand-gated Ion Channels
    • Rhodopsin-like receptors and pumps
    • Single-helix ATPase Regulators
    • Squalene/ phytoene Synthase
    • Stearoyl -CoA desaturase 1
    • Stannin (SNN) Membrane Proteins
    • T-cell Surface Glycoprotein CD3 Zeta Chain
    • Tetratricopeptide repeat (TPR) Alpha-Helical Repeat Proteins
    • Transmembrane Proteins with NAD(P)-binding Rossmann-fold Domains
    • Monotypic/Peripheral Protein Production
    • Alpha/Beta-Hydrolase
    • Annexins
    • Bet V1-Like Protein
    • C1 Domain-Containing Protein
    • C2 Domain-containing Protein
    • CoA-Dependent Acyltransferases
    • CRAL-TRIO Domain-Containing
    • Protein
    • DNase I-like protein
    • Fibrinogen
    • FYVE/PHD Zinc Finger Protein
    • Galactose-Binding Domain-Like Protein
    • Glycolipid Transfer Protein
    • Immunoglobulin-Like Superfamily (E Set) Protein
    • Lipocalin
    • Lipoxygenase
    • PGBD superfamily
    • PH Domain-Like Protein
    • Phosphatidylinositol 3-/4-Kinase
    • PLC-like Phosphodiesterase
    • Phosphotyrosine Protein Phosphatases II
    • P-Loop Containing Nucleoside Triphosphate Hydrolase
    • Protein kinase superfamily
    • PX Domain-Containing Protein
    • Saposin
    • Synuclein
    • Transcriptional factor tubby

    Here is the end of the introduction of membrane proteins, I hope this article can help you better understand membrane proteins.